| Rnd | Team | Match Date | Home Team | Result | Away Team |
|---|
| 1 | First XI | 1980-10-04 | Murrumbeena | lost to | Spotswood |
| 9/94 P Hay 28 | | 97 J Graham 3/22 P Way 5/22 |
| 3 | First XI | 1980-10-18 | Murrumbeena |  | Bentleigh |
| 186 P Hay 38 J Graham 39
and 1/6 | | 165 J Graham 2/36 P Way 2/36 A Graham 2/37 J McMahon 2/18 |
| 5 | First XI | 1980-11-15 | Brunswick District | | Murrumbeena |
| 108 J Graham 4/18 R Parker 3/15 J McMahon 2/32
and 4/101 R Parker 2/28 | | 7/179 J Graham 39 D Hardham 66* |
| 6 | First XI | 1980-11-29 | Murrumbeena | | Hampton |
| 123
and 6/85 P Hay 44* | | 116 J Graham 7/35 A Graham 2/22
and 5/108 P Way 2/27 |
| 8 | First XI | 1981-01-17 | Murrumbeena | lost to | South Caulfield |
| 83 | | 5/124 P Way 3/38 |
| 9 | First XI | 1981-01-24 | Altona North | def | Murrumbeena |
| 254 A Graham 2/56 P Way 4/28 | | 147 D Hardham 31 |
| 10 | First XI | 1981-01-26 | Murrumbeena | | Highett |
| 139 G Hickey 33 P Way 25 | | 86 J Graham 2/14 R Parker 3/38 S Goold 2/13 |
| 11 | First XI | 1981-02-14 | Moorabbin Park | def | Murrumbeena |
| 8/177 J Graham 2/36 D Hardham 2/34 P Way 2/36 S Goold 2/28 | | 9/103 P Hay 38 |
| 12 | First XI | 1981-02-21 | Murrumbeena | lost to | Altona North |
| 161 D Hardham 27 A Graham 55
and 107 | | 187 D Hardham 3/20 P Way 6/42 |
